Resume

2017-present, College of Life Sciences, Shandong Normal University, Instructor

2011-2017, Shanghai Institute for Biological Science, The Chinese Academy of Sciences, Ph.D.

2007-2011, College of Life Sciences, Shandong Normal University, B.S.

Research Areas

Infertility has become a worldwide health problem. The development of mammalian follicles is precisely regulated, and the quantity and quality of follicles determine the reproductive lifespan of women. How the programmed cell death pathway regulates follicle development remains unclear. We use gene knockout mice to explore the role of cell death pathway in follicle development through various experimental methods including cell biology, biochemistry and molecular biology, and then provide theoretical basis for the diagnosis and treatment of related diseases.

Key words: Apoptosis; Necrosis; Follicle; Infertility and Sterility; Reproductive Health

Honors and Awards

N/A

Selected Publications

1.Cunxian Fan*, Xiao Yang *, Hui Nie, Shunxin Wang, Liangran Zhang. Per-nucleus crossover covariation is regulated by chromosome organization. iScience. 2022 Mar 18;25(4):104115. doi: 10.1016/j.isci.2022.104115. eCollection 2022 Apr 15. (*:co-first author)

2.Cunxian Fan*, Wenjuan Pu*, Xiaoxia Wu, Xixi Zhang, Lingjuan He, Bin Zhou and Haibing Zhang, Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality. Cell Death and Disease (2016) 7, e2351; doi:10.1038/cddis.2016.251(*:co-first author)

3.Xixi Zhang*, Cunxian Fan*, Haiwei Zhang, Qun Zhao, Yongbo Liu, Chengxian Xu, Qun Xie, Xiaoxia Wu, Xianjun Yu, Jianke Zhang, and Haibing Zhang. MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome. Cell Reports16, 3247–3259 September 20, 2016(*:co-first author)

4.Yongbo Liu*, Cunxian Fan*, Yifan Zhang, Xianjun Yu, Xiaoxia Wu, Xixi Zhang, QunZhao, Haiwei Zhang, QunXie, Ming Li, Xiaoming Li, Qiurong Ding, Hao Ying, Dali Li and Haibing Zhang. RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice. Cell Death and Differentiation. 2 June 2017; doi:10.1038/cdd.2017.78(*:co-first author)

5. Shang Y, Tan T, Fan C, Nie H, Wang Y, Yang X, Zhai B, Wang S, Zhang L. Meiotic chromosome organization and crossover patterns. Biol Reprod. 2022 Feb 22: ioac040. doi: 10.1093/biolre/ioac040.

6.Songbo Xie, Linlin Zhang, Dan Dong , Ruixin Ge, Qianqian He, Cunxian Fan, Wei Xie, Jun Zhou, Dengwen Li, and Min Liu.HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21.J Biol Chem. 2020 Oct 16;295(42). 5. Chengxian Xu, Xiaoxia Wu, Xixi Zhang, Qun Xie,Cunxian Fan, and Haibing Zhang. Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis.Journal of Immunology. 2017.11.22

7. Xu C, Wu X, Zhang X, Xie Q, Fan C, Zhang H. Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis. J Immunol. 2018 Jan 1;200(1):271-285. doi: 10.4049/jimmunol.1700859.

Group Members

Current Members:

Qi Sun, Haifei Qi, Xiaoyu Song

Past Members:

N/A

E-mail：fancunxian@sdnu.edu.cn

Telephone：

Office addr：Room 505, College of Life Sciences, Shandong Normal University