个人履历

2017-至今，山东师范大学，生命科学学院，讲师

2011-2017,中国科学院上海生命科学研究院，生物化学与分子生物学，博士

2007-2011,山东师范大学，生命科学学院，学士

主要研究方向

不孕不育已成为世界范围内的健康问题，哺乳动物卵泡发育过程受到精确调控，卵泡的数量和质量决定了女性的生殖寿命。而程序性细胞死亡通路如何调控卵泡发育过程，依然不清楚。我们利用基因敲除小鼠，通过细胞生物学、生物化学与分子生物学等多种实验手段，来探究细胞死亡通路在卵泡发育过程中的作用，进而为相关疾病诊断和治疗提供理论依据。

关键词：细胞凋亡；细胞坏死；卵泡；不孕不育；生殖健康

获奖及荣誉

无

代表性论文及论著

1. Cunxian Fan*, Xiao Yang *, Hui Nie, Shunxin Wang, Liangran Zhang. Per-nucleus crossover covariation is regulated by chromosome organization. iScience. 2022 Mar 18;25(4):104115. doi: 10.1016/j.isci.2022.104115. eCollection 2022 Apr 15. (*:co-first author)

2.Cunxian Fan*, Wenjuan Pu*, Xiaoxia Wu, Xixi Zhang, Lingjuan He, Bin Zhou and Haibing Zhang, Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality. Cell Death and Disease (2016) 7, e2351; doi:10.1038/cddis.2016.251(*:co-first author)

3.Xixi Zhang*, Cunxian Fan*, Haiwei Zhang, Qun Zhao, Yongbo Liu, Chengxian Xu, Qun Xie, Xiaoxia Wu, Xianjun Yu, Jianke Zhang, and Haibing Zhang. MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome. Cell Reports16, 3247–3259 September 20, 2016(*:co-first author)

4.Yongbo Liu*, Cunxian Fan*, Yifan Zhang, Xianjun Yu, Xiaoxia Wu, Xixi Zhang, QunZhao, Haiwei Zhang, QunXie, Ming Li, Xiaoming Li, Qiurong Ding, Hao Ying, Dali Li and Haibing Zhang. RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice. Cell Death and Differentiation. 2 June 2017; doi:10.1038/cdd.2017.78(*:co-first author)

5. Shang Y, Tan T, Fan C, Nie H, Wang Y, Yang X, Zhai B, Wang S, Zhang L. Meiotic chromosome organization and crossover patterns. Biol Reprod. 2022 Feb 22: ioac040. doi: 10.1093/biolre/ioac040.

6.Songbo Xie, Linlin Zhang, Dan Dong , Ruixin Ge, Qianqian He, Cunxian Fan, Wei Xie, Jun Zhou, Dengwen Li, and Min Liu.HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21.J Biol Chem. 2020 Oct 16;295(42). 5. Chengxian Xu, Xiaoxia Wu, Xixi Zhang, Qun Xie,Cunxian Fan, and Haibing Zhang. Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis.Journal of Immunology. 2017.11.22

7. Xu C, Wu X, Zhang X, Xie Q, Fan C, Zhang H. Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis. J Immunol. 2018 Jan 1;200(1):271-285. doi: 10.4049/jimmunol.1700859.

组员

目前成员：

孙琪，戚海飞，宋啸宇

过去成员：

暂无

E-mail：fancunxian@sdnu.edu.cn

办公电话：

办公地点：山东省济南市长清区大学路1号山东师范大学长清湖校区博物楼A座505室