Resume
2015-Present, College of Life Sciences, Shandong Normal University, Professor
2005- Present, College of Life Sciences, Nankai University, Professor
2003-2005, School of Medicine, Emory University, Instructor
2002-2003, Genentech, Inc., Postdoctoral fellow
1999-2002, Emory University, Ph.D.
1997-1999, Peking University, M.S. student
1992-1997, Fudan University, B.S.
Research Areas
The microtubule cytoskeleton plays a critical role in a number of cellular activities and is essential for the growth and development of organisms. Together with various protein complexes, microtubules form complicated but elegant cellular structures and exhibit intriguing behaviors. Our research focuses on the dynamic structures and functions of microtubules in cellular processes, tissue/organ development, and human diseases. We tackle these questions using advanced technologies across multiple disciplines. Our work is supported by grants from the National Natural Science Foundation of China and the Ministry of Science and Technology of China.
Key words: microtubule, centrosome, spindle, cilium, cell division, cell motility, tissue/organ development, human disease
Honors and Awards
2016, Leading Talent, Taishan Scholar Program, Shandong Province
2010, Young Scholar Award, Fok Ying-Tong Education Foundation
2008, National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China
Selected Publications
Ran J, Zhang Y, Zhang S, Li H, Zhang L, Li Q, Qin J, Li D, Sun L, Xie S, Zhang X, Liu L, Liu M,Zhou J. Targeting the HDAC6-cilium axis ameliorates the pathological changes associated with retinopathy of prematurity. Adv Sci. 2022;e2105365.
Zhong T, Wu X, Xie W, Luo X, Song T, Sun S, Luo Y, Li D, Liu M, Xie S,Zhou J.ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes. Cell Death Differ. 2022.
Song T, Yang Y, Zhou P, Ran J, Zhang L, Wu X, Xie W, Zhong T, Liu H, Liu M, Li D, Zhao H,Zhou J.ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO Rep. 2022.
Yang Y, Chen M, Li JR, Hong RJ, Yang J, Yu F, Li T, Yang S, Ran J, Guo CY, Zhao Y, Luan Y, Liu M, Li DW, Xie SB,Zhou J.A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis. Sci Bull. 2021;66(7):727-39.
Ma H, Qi F, Ji L, Xie S, Ran J, Liu M, Gao J,Zhou J.NuMA forms condensates through phase separation to drive spindle pole assembly. J Mol Cell Biol. 2022;14(1):mjab081.
Yu F, Li T, Sui Y, Chen Q, Yang S, Yang J, Hong R, Li D, Yan X, Zhao W, Zhu X,Zhou J.O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis. Protein Cell. 2020;11(11):852-7.
Xie W, Li D, Dong D, Li Y, Zhang Y, Duan L, Liu X, Meng W, Liu M,Zhou J.HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions. Signal Transduct Target Ther. 2020;5(1):79.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X,Zhou J.ASK1-mediated phosphorylation blocks HDAC6 ubiquitination and degradation to drive the disassembly of photoreceptor connecting cilia. Dev Cell. 2020;53(3):287-99.
Du X, Zhang Z, Zheng X, Zhang H, Dong D, Zhang Z, Liu M,Zhou J.An electrochemical biosensor for the detection of epithelial-mesenchymal transition. Nat Commun. 2020;11(1):192.
Yu F, Guo S, Li T, Ran J, Zhao W, Li D, Liu M, Yan X, Yang X, Zhu X,Zhou J.Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res. 2019;29(2):171-3.
Group Members
Current Members:
Staffs and postdocs:Xiaoqian Meng, Min Liu, Yijie Wang, Jie Ran, Yue Wu, Yanjie Tan, Yiming Kong, Yan Li, Wei Pan, Ting Song
Lab managers:Runa Wang
Ph.D. students:Na He, Renshuai Zhang, Yuyang Li, Yigao Zhu, Lulu Sun, Ruixin Ge, Qian Lyu
Past Members:
Lab managers:Dongxue Tang, Xiaoxiao Song, Wenbo Li, Jun Qiu, Mingzheng Hu
Ph.D. students:Miao Chen, Peng Zhou, Tao Zhong, Huixian Ma, Jingrui Li, Ting Song, Lisheng Liu
E-mail：junzhou@sdnu.edu.cn
Telephone：0531-86182518
Office addr：Room 550, College of Life Sciences, Shandong Normal University
