先后就读于复旦大学、北京大学和美国埃默里大学，并在美国基因泰克公司和埃默里大学接受科研训练。曾任南开大学生命科学学院副院长、美国佐治亚理工学院访问教授等。现为中国细胞生物学学会资深理事，中国遗传学会理事，四种国际期刊的编委。
微管细胞骨架参与细胞分裂、细胞运动等众多细胞活动，对于生物体的生长和发育至关重要。微管还与种类繁多的蛋白质复合物一起，组成中心体、纺锤体、纤毛等复杂而精巧的细胞结构，表现出令人困惑却又十分有趣的行为。我们课题组利用多学科交叉的前沿技术，聚焦于微管在细胞活动、组织器官发育以及人类疾病中的动态结构与功能。这些研究获得国家自然科学基金委员会、科技部等部门的资助。
Ran J, Zhang Y, Zhang S, Li H, Zhang L, Li Q, Qin J, Li D, Sun L, Xie S, Zhang X, Liu L, Liu M,Zhou J. Targeting the HDAC6-cilium axis ameliorates the pathological changes associated with retinopathy of prematurity. Adv Sci. 2022;e2105365.
Zhong T, Wu X, Xie W, Luo X, Song T, Sun S, Luo Y, Li D, Liu M, Xie S,Zhou J.ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes. Cell Death Differ. 2022.
Song T, Yang Y, Zhou P, Ran J, Zhang L, Wu X, Xie W, Zhong T, Liu H, Liu M, Li D, Zhao H,Zhou J.ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO Rep. 2022.
Yang Y, Chen M, Li JR, Hong RJ, Yang J, Yu F, Li T, Yang S, Ran J, Guo CY, Zhao Y, Luan Y, Liu M, Li DW, Xie SB,Zhou J.A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis. Sci Bull. 2021;66(7):727-39.
Ma H, Qi F, Ji L, Xie S, Ran J, Liu M, Gao J,Zhou J.NuMA forms condensates through phase separation to drive spindle pole assembly. J Mol Cell Biol. 2022;14(1):mjab081.
Yu F, Li T, Sui Y, Chen Q, Yang S, Yang J, Hong R, Li D, Yan X, Zhao W, Zhu X,Zhou J.O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis. Protein Cell. 2020;11(11):852-7.
Xie W, Li D, Dong D, Li Y, Zhang Y, Duan L, Liu X, Meng W, Liu M,Zhou J.HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions. Signal Transduct Target Ther. 2020;5(1):79.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X,Zhou J.ASK1-mediated phosphorylation blocks HDAC6 ubiquitination and degradation to drive the disassembly of photoreceptor connecting cilia. Dev Cell. 2020;53(3):287-99.
Du X, Zhang Z, Zheng X, Zhang H, Dong D, Zhang Z, Liu M,Zhou J.An electrochemical biosensor for the detection of epithelial-mesenchymal transition. Nat Commun. 2020;11(1):192.
Yu F, Guo S, Li T, Ran J, Zhao W, Li D, Liu M, Yan X, Yang X, Zhu X,Zhou J.Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res. 2019;29(2):171-3.
