Resume

2022-Present, College of Life Sciences, Shandong Normal University, Professor

2016-2021, Southwestern Medical Center, Postdoctoral fellow

2011-2016, Zhejiang University, Ph.D.

2007-2011, Henan University, B.S.

Research Areas

Cytoskeleton and related organelles play pivotal roles in many cellular activities, such as shape arrangement, intracellular transport, signal transduction, cell movement and cell division. Abnormalities of these organelles are always correlated with the occurrence and development of tumors. In addition to cancer cells themselves, the tumor microenvironment also plays a crucial role in cancer development. We are aiming to explore the role of cytoskeleton and tumor microenvironment in carcinogenesis and understand their regulatory mechanisms. Our goal is to fully understand the mechanism of carcinogenesis and provide novel targets as well as strategies for cancer diagnosis and treatment.

1. Role of cilia and centrosome abnormalities in cancer progression.

2. Role of hypoxia and related signals in cancer progression.

Key words:Tumor growth and metastasis; Cilia; Centrosome; Hypoxia; Post-translational modification

Honors and Awards

2022，Shandong Science Fund for Excellent Young Scholars (Overseas)

Selected Publications

1. Wang, Y., Chen, Y., Wang, C., Yang, M., Wang, Y., Bao, L., Wang, J.E., Kim, B., Chan, K.Y., Xu, W., et al. (2021). MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth. Nat Commun 12, 2954.

2. Wang, Y.*, Chen, Y.*, Bao, L., Zhang, B., Wang, J.E., Kumar, A., Xing, C., Wang, Y., and Luo, W. (2020). CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors. Cancer Res 80, 3880-3891.

3. Wang, Y.*, Li, G.*, Deng, M., Liu, X., Huang, W., Zhang, Y., Liu, M., and Chen, Y. (2021). The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics. Pharmacol Ther 221, 107783.

4. Chen, Y.#, Liu, M., Niu, Y., andWang, Y#. (2020). Romance of the three kingdoms in hypoxia: HIFs, epigenetic regulators, and chromatin reprogramming. Cancer Lett 495, 211-223.

5. Wang, Y. J., Luo, W. B., and Wang, Y. F. (2019). PARP-1 and its associated nucleases in DNA damage response. DNA Repair 81.

6. Cao, J.*,Wang, Y.*, Dong, R., Lin, G., Zhang, N., Wang, J., Lin, N., Gu, Y., Ding, L., Ying, M., et al. (2015). Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells. Cancer Res 75, 4839-4851.

7. Wang, Y., Luo, M., Chen, Y.,Wang, Y., Zhang, B., Ren, Z., Bao, L., Wang, Y., Wang, J. E., Fu, Y. X., et al. (2021). ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth. Cancer Res 81, 174-186.

Group Members

Current Members:

MingzhengHu,Ph.D. student（2022class）

Miaomiao Zheng,M.S. student（2021class）

Lichun Wang, M.S. student（2021class）

PastMembers:

N/A

E-mail：yijiewang@sdnu.edu.cn

Telephone：

Office addr：Room 550, College of Life Sciences, Shandong Normal University