细胞骨架及相关细胞器在形态维持、胞内运输、信号传递、细胞运动及细胞分裂等众多生命活动中发挥着广泛作用，这些细胞器的异常往往伴随着肿瘤的发生发展。除癌细胞本身外，肿瘤微环境在癌症发展过程中也扮演着至关重要的角色。我们主要以细胞骨架及肿瘤微环境为切入点，阐明两者在癌发生发展中的作用，探索细胞器异常和重塑微环境以利于自身恶性行为演进的分子机制，为全面理解癌发生发展的机理提供新思路，并为癌症诊断、治疗提供新靶点新策略。
1. 细胞骨架在肿瘤发展过程中的作用：
2. 肿瘤低氧微环境对肿瘤发生、发展及转移的影响：
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