Resume
2021-Present, College of Life Sciences, Shandong Normal University, Instructor
2018-2020, Ohio State University, Research Associate
2011-2015, Shandong University, Ph.D.
2008-2011, Shandong Academy of Medical Sciences, M.S.
2004-2008, Taishan Medical College, B.S.
Research Areas
Targeted protein degradation (TPD) is a novel drug discovery strategy that eradicates problem proteins from cells by hijacking cellular degradation processes with small molecules. Different from the development of traditional therapies using small-molecule drugs is based on modulating protein function and activity through the occupation of active sites such as enzyme inhibition or ligand-receptor binding, TDP therapies modulate protein degradation system of the host（ubiquitin-proteasome and lysosomal degradation system）. TPD includes several different types of technology. For example, Lysosome-targeting chimaeras, in which a small molecule or antibody is connected to a glycopeptide ligand to form a conjugate that can bind a cell-surface lysosome-shuttling receptor (IGF2R, which mediate the transport of proteins to lysosomes and subsequent degradation) and a protein target-are used to achieve the targeted degradation of extracellular and membrane proteins. Based on LYTAC technology, we designed chimeras targeting key proteins in diseases to provide new strategies for disease treatment by degrading key proteins.
Key words:TPD， LYTAC，IGF2R，Target protein，Disease
Honors and Awards
N/A
Selected Publications
Li Y, Liu M, Zuo Z, et al. TLR9 Regulates the NF-kappaB-NLRP3-IL-1beta Pathway Negatively in Salmonella-Induced NKG2D-Mediated Intestinal Inflammation. J Immunol. Jul 15 2017;199(2):761-773. doi:10.4049/jimmunol.1601416
Li T, Kong L, Li X, Wu S, Attri K,Li Y, et al. Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy. Nat Microbiol. Mar 2021;6(3):366-379. doi:10.1038/s41564-020-00843-2
Wang Y, Guan Y, Hu Y,Li Y, Lu N, Zhang C. Murine CXCR3(+)CXCR6(+)gammadeltaT Cells Reside in the Liver and Provide Protection Against HBV Infection. Front Immunol. 2021;12:757379. doi:10.3389/fimmu.2021.757379
Yang H, Xu W,Li Y, et al. Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by inducing p21WAF1 expression and cell cycle arrest. Anticancer Drugs. Aug 2014;25(7):767-77. doi:10.1097/CAD.0000000000000101
Group Members
Current Members:
Jian Song, M.S. student（2021 class）
Past Members:
N/A
E-mail：yanli@sdnu.edu.cn
Telephone：
Office addr：Room 551, College of Life Sciences, Shandong Normal University
