Jinmin GaoProfessorResume
2017-Present, College of Life Sciences, Shandong Normal University, Professor
2010-2017, Harvard Medical School, Postdoctoral fellow
2005-2010, Nankai University, Ph.D.
2001-2005, Nankai University, B.S.
Research Areas
Sexually reproducing organisms produce haploid gametes through meiosis, a specialized cell division program, to transmit genetic information. Accurate segregation of meiotic chromosomes relies on a series of meiosis-specific events. Dysregulation of these events can lead to aneuploidy, causing birth defects (such as Down syndrome) and other diseases such as infertility and miscarriages in humans. Research in the Gao Lab uses Caenorhabditis elegans as the main in vivo research model to elucidate the assembly and regulation of meiosis-specific structures and explore the internal and external factors causing abnormal meiotic chromosome segregation.
Key words:Sexual Reproduction; Meiosis; Caenorhabditis elegans; Aneuploidy
Honors and Awards
National Science Fund for Excellent Young Scholars
Selected Publications
Alterations in synaptonemal complex coding genes and human infertility. Zhang F, Liu M,Gao J. Int J Biol Sci. 2022; 18(5):1933-1943
The organization, regulation, and biological functions of the synaptonemal complex.Zhang F, Zhang R,Gao J. Asian J Androl. 2021 Nov-Dec;23(6):580-589.
SYP-5 regulates meiotic thermotolerance in Caenorhabditis elegans. Liu Y, Zhao Q, Nie H, Zhang F, Fu T, Zhang Z, Qi F, Wang R, Zhou J,Gao J. J Mol Cell Biol. 2021 Dec 6;13(9):662-675.
Multivalent weak interactions between assembly units drive synaptonemal complex formation. Zhang Z, Xie S, Wang R, Guo S, Zhao Q, Nie H, Liu Y, Zhang F, Chen M, Liu L, Meng X, Liu M, Zhao L, Colaiácovo MP, Zhou J,Gao J. J Cell Biol. 2020 May 4;219(5):e201910086. (Cover story)
Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics.Gao J, Colaiácovo MP. Trends Genet. 2018 Mar;34(3):232-245.
N-terminal acetylation promotes synaptonemal complex assembly in C. elegans.Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP. Genes Dev. 2016 Nov 1;30(21):2404-2416. (Cover story)
NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis.Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP. PLoS Genet. 2015 Mar 13;11(3):e1005029.
CYLD regulates angiogenesis by mediating vascular endothelial cell migration.Gao J, Sun L, Huo L, Liu M, Li D, Zhou J. Blood. 2010 May 20;115(20):4130-7.
EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. Sun L,Gao J, Dong X, Liu M, Li D, Shi X, Dong JT, Lu X, Liu C, Zhou J. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7153-8.
The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration.Gao J, Huo L, Sun X, Liu M, Li D, Dong JT, Zhou J. J Biol Chem. 2008 Apr 4;283(14):8802-9.
Group Members
Current Members:
Ruoxi Wang, Ph.D., Lecturer
Feifei Qi, Ph.D., Lecturer
Fengguo Zhang, Ph.D. student (2018 class)
Zhang Ruirui, Ph.D. student (2020 class)
Yuanyuan Liu, Ph.D. student (2021 class)
Libo Liu, M.S. student（2019 class）
Jiaxiang Li, M.S. student（2019 class）
Tingting Fu, M.S. student（2019 class）
Ruijie Jiang, M.S. student（2020 class）
Mengfei Liu, M.S. student（2020 class）
Xing Zhang, M.S. student（2021 class）
E-mail：jinmingao@sdnu.edu
Telephone：
Office addr：Room 532, College of Life Sciences, Shandong Normal University
