Resume

2022-Present, Shandong Normal University, Lecturer

2017-2022, Shandong University, Postdoctoral Researcher

2010-2017, Shandong University, D. Phil

2014-2015, University of California, Riverside, Joint Training PhD

2006-2010, Northwest Normal University, BS

Research Areas

Meiosis is essential for sexual reproduction and homologous recombination is the key event of meiosis. Homologous recombination begins with programmed formation of DNA double-strand breaks, which are repaired to crossovers and non-crossovers. Crossovers not only physically connect homologous chromosomes via promoting proper homologous chromosome segregation, but also give rise to reciprocal exchange of homologous chromosomes via promoting genetic diversity. Aberrant recombination often leads to gametogenic failure or produces aneuploid gametes, which in turn can cause serious reproductive problems, such as human infertility, spontaneous abortion or congenital birth defects, and crop sterility. We mainly use Saccharomyces cerevisiae as a model organism to study the process and regulation of meiotic recombination with various methods in cell biology, genetics and biochemistry, including the identification of key homologous recombination factors and analysis of their functions and molecular mechanisms.

Key words: Yeast; Meiosis; Homologous recombination; DNA double strand break

Honors and Awards

N/A

Selected Publications

1. RNA-DNA hybrids regulate meiotic recombination. Xuan Yang#; Binyuan Zhai#; Shunxin Wang#; Xiangfei Kong; Yingjin Tan; Lin Liu; Xiao Yang; Taicong Tan; Shuxian Zhang; Liangran Zhang. Cell Reports, 2021, 37(110097). DOI: 10.1016/j.celrep.2021.110097.

2. Structure and function of a novel ATPase that interacts with Holliday junction resolvase Hjc and promotes branch migration. Binyuan Zhai; Kevin DuPrez; Tzanko I. Doukov; Huan Li; Mengting Huang; Guijun Shang; Jinfeng Ni; Lichuan Gu; Yulong Shen; Li Fan. Journal of Molecular Biology, 2017, 429(7): 1009-1029. DOI: 10.1016/j.jmb.2017.02.016

3. The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. Binyuan Zhai; Kevin DuPrez; Xiaoyun Han; Zenglin Yuan; Sohail Ahmad; Cheng Xu; Lichuan Gu; Jinfeng Ni; Li Fan; Yulong Shen. Nucleic Acids Research, 2018, 46(13): 6627-6641. DOI: 10.1093/nar/gky451

Group Members

N/A

E-mail：king19870927@126.com

Telephone：

Office addr：Room 526, College of Life Sciences, Shandong Normal University