Resume
2022-Present, College of Life Sciences, Shandong Normal University, Professor
2017-2021, National Cancer Institute, National Institutes of Health, Postdoctoral fellow
2014-2017, Shanghai Institute of Biochemistry and Cell Biology, CAS, Postdoctoral fellow
2007-2013, Shanghai Institute of Biochemistry and Cell Biology, CAS, Ph.D.
2003-2007, School of Life Sciences, Nanjing University, B.S.
Research Areas
Cilia are microtubule-based hair-like organelles, which are composed of basal body, transition zone, axoneme, and ciliary membrane, and protrude from the surface of most vertebrate cells and play crucial roles in signaling transduction, cell motility, and tissue homeostasis. Given the important roles in chemical sensation and signal transduction, ciliary dysfunction can cause multiple severe human diseases, referred to as ciliopathies. Using cell, zebrafish and mouse models along with cutting-edge cellular imaging, biochemistry, proteomics and genetics systems we study regulation of ciliogenesis and function in development and human disorders. Our focus has been on understanding the roles of cytoskeleton regulators, centrosomal and ciliary components in ciliogenesis and ciliary function. We aim to investigate the physiological significance of centrosome and cilia, understand the physiological perspective of human ciliopathies, and improve the ciliopathy-related diagnostics test and clinical treatment.
Key words:Centrosome, Cilia and related human diseases
Honors and Awards
2013，National Scholarship
2014，Special Prize of President Scholarship for Postgraduate Students, CAS
2014，Outstanding Graduate of University of Chinese Academy of Sciences (CAS)
2014，Shanghai Oustanding Graduates
2015，Shanghai Excellece Awards for Graduates
2015，Sanofi-SIBS Distinguish Young Scientist Award
2022，Shandong Science Fund for Excellent Young Scholars (Overseas)
Selected Publications
Zhao H,Sun J, Insinna C, et al. Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery. EMBO Rep. Feb 24 2022:e52775. doi:10.15252/embr.202152775
Zhao H,Chen Q, Li F, et al. Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly. Nat Commun. Feb 24 2021;12(1):1273. doi:10.1038/s41467-021-21506-8
Zhao H,Yang S, Chen Q, et al. Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis. J Cell Sci. Jul 3 2020;133(13)doi:10.1242/jcs.241836
Zheng J, Liu H, Zhu L, et al. Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation. J Mol Cell Biol. Jan 1 2019;11(1):67-77. doi:10.1093/jmcb/mjy014
Zhao H,Chen Q, Fang C, et al. Parental centrioles are dispensable for deuterosome formation and function during basal body amplification. EMBO Rep. Apr 2019;20(4)doi:10.15252/embr.201846735
Cuenca A, Insinna C,Zhao H,et al. The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis. J Biol Chem. Oct 18 2019;294(42):15418-15434. doi:10.1074/jbc.RA119.008615
Yan X,Zhao H,Zhu X. Production of Basal Bodies in bulk for dense multicilia formation. F1000Res. 2016;5doi:10.12688/f1000research.8469.1
Zhao H, Zhu L, Zhu Y, et al. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol. Dec 2013;15(12):1434-44. doi:10.1038/ncb2880
Zhao H,Zhu L, Jin Y, Ji H, Yan X, Zhu X. miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells. Acta Biochim Biophys Sin (Shanghai). Feb 2012;44(2):177-82. doi:10.1093/abbs/gmr110
Group Members
Current Members:
Qingchao Li, Instructor
Yigao Zhu, Ph.D. student（2020 class）
Bingkun Kang, M.S. student（2020 class）
Fangyuan Liu, M.S. student（2021 class）
Huixin Shen, M.S. student（2021 class）
Past Members:
N/A
E-mail：huijiezhao@sdnu.edu.cn
Telephone：0531-86182518
Office addr：Room 544, College of Life Sciences, Shandong Normal University
