Resume

2021-Present, College of Life Sciences, Shandong Normal University, Associate Professor

2016-2020, College of Life Sciences, Shandong Normal University, Instructor

2015-2016, College of Pharmacy, Shandong University, Postdoctoral fellow

2008-2014, College of life sciences, Xiamen University, Ph.D.

2004-2008, College of life sciences, Xiamen University, B.S.

Research Areas

Cell junction, mainly between epithelial cells, is the structural basis of cellular networks and an important organizational mode of synergistic interaction between adjacent cells in multicellular organisms. Disruption of cell junction homeostasis often leads to pathological change in multicellular organisms. Our main research work is to study the molecular mechanism involved in regulating cell junction homeostasis by using cells and animal models, including: (1) the role of microtubules and autophagy in the regulation of cell junction homeostasis, (2) the molecular mechanism of the occurrence and development of cell junction-related diseases. Our research has been funded by the National Natural Science Foundation of China (Role of autophagy in HIV gp120-induced intestinal epithelial permeability and related molecular mechanisms, 31701209), the Cultivation Fund of Shandong Normal University, and the Postdoctoral Innovation Fund of Shandong Province.

Key words:Cell junction, cytoskeleton, microtubule, microtubule-binding protein, autophagy

Honors and Awards

N/A

Selected Publications

1. Xie W, Chen M, Zhai Z, et al. HIV-1 exposure promotes PKG1-mediated phosphorylation and degradation of stathmin to increase epithelial barrier permeability. J Biol Chem. Jan-Jun 2021;296:100644. doi:10.1016/j.jbc.2021.100644

2. Xie W, Li D, Dong D, et al. HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions. Signal Transduct Target Ther. Jun 19 2020;5(1):79. doi:10.1038/s41392-020-0175-1

3. Xie W, Zhou J. Aberrant regulation of autophagy in mammalian diseases. Biol Lett. Jan 2018;14(1). doi:10.1098/rsbl.2017.0540

4. Xie W, Zhang W, Sun M, Lu C, Shen Y. Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis. Appl Microbiol Biotechnol. Jul 2018;102(14):5965-5975. doi:10.1007/s00253-018-9058-6

5. Xie W, Zhou J. Regulation of mitotic spindle orientation during epidermal stratification. J Cell Physiol. Jul 2017;232(7):1634-1639. doi:10.1002/jcp.25750

6. Xie W, Yang Y, Gao S, et al. The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly. J Genet Genomics. Jul 20 2017;44(7):343-353. doi:10.1016/j.jgg.2017.06.002

7. Xie W, Zhang L, Jiao H, et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy. 2015;11(9):1623-35. doi:10.1080/15548627.2015.1075688

Group Members

Current Members:

Mingzhen, Chen, M.S. student（2019 class）

Ye, Lv, M.S. student（2019 class）

Hongjie, Li, M.S. student（2020 class）

Junyan, Zhou, M.S. student（2021 class）

Past Members:

Ting, Song, M.S. student（2016 class）

Dan, Dong, M.S. student（2017 class）

Zhaodong, Zhai, M.S. student（2018 class）

E-mail：wxie@sdnu.edu.cn

Telephone：

Office addr：Room 533, College of Life Sciences, Shandong Normal University