Resume
2020-Present, College of Life Sciences, Shandong Normal University, Instructor
2015-2020, Nankai University, Ph.D.
2011-2015, Shandong Normal University, B.S.
Research Areas
Primary cilia and Adipose Tissue Homeostasis. Primary cilia are microtubule-based organelles that are widely found on the surface of various cells, resembling "antennae" extending from the cell membrane, and are very conserved information gathering hub and dispersal organelles in the evolutionary process, which are involved in cell proliferation, differentiation, signal transduction, autophagy, migration, polarity and other life processes. The diverse functions are associated with the expression of high-density membrane receptors on cilia. The cilium structure includes the matrix, transition zone, internal axoneme skeleton, cilium membrane and cilium tip, which are about 1~10 μm in length. Primary cilia are present on the surface of almost all eukaryotic cells and participate in signaling processes such as Hedgehog, Wnt, PDGFR-α, Notch, and mTOR by coordinating the transport and localization of various signaling molecules and receptors. Mutations in ciliary structural proteins and associated accessory proteins, which are required for the integrity and function of the primary cilia, result in ciliary degradation or dysfunction. Diseases involving mutations in genes encoding ciliary structural proteins or accessory proteins are collectively referred to as " ciliopathies ". White adipose tissue (WAT) plays an important role in regulating systemic metabolic homeostasis and the occurrence and progression of metabolic cardiovascular diseases. Cilia signaling dysfunction is closely associated with the development of metabolic diseases such as obesity, insulin resistance and type 2 diabetes, therefore, it is important to study the regulation of adipose tissue homeostasis by cilia for the treatment of metabolic diseases.
Undertake project:
(1) National Natural Science Foundation of China, Young Scientists Foundation Project, 32100614, Regulation of HDAC6 by Arginine Methylation Modification, 2022-01-01 to 2024-12-31, RMB 300,000, Under Research, Host
(2) Natural Science Foundation of Shandong Province, Youth Project, ZR2021QC069, Regulation of HDAC6 Protein Stability and Function by Arginine Methylation Modification, 2022-01 to 2024-12, RMB 150,000, Under Research, Host
Key words:cilium, adipose tissue homeostasis, cell signal transduction, post-translational modifications, cell motility
Honors and Awards
N/A
Selected Publications
Wu, Yue; Wang, Xue; Xu, Feifei; Zhang, Lu; Wang, Tianjiao; Fu, Xueli; Jin, Tianzhi; Zhang, Weiying; Ye, Lihong.The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt–PCAF pathway in promotion of esophageal squamous cell carcinoma growth. Nucleic Acids Research. 2020, 48(9): 4858-4876. Doi: 10.1093/nar/gkaa232.
Song, Ting; Zhou, Peng; Sun, Chunjiao; He, Na; Li, Haixia; Ran, Jie; Zhou, Jun;Wu, Yue; Liu, Min. Enkurin domain containing 1 (ENKD1) regulates the proliferation, migration and invasion of nonsmall cell lung cancer cells. Asia-Pacific Journal of Clinical Oncology. 2021 Mar 15. Doi: 10.1111/ajco.13550.
Wang, Tianjiao; Fu, Xueli; Jin, Tianzhi; Zhang, Lu; Liu, Bowen;Wu, Yue; Xu, Feifei; Wang, Xue; Ye, Kai; Zhang, Weiying; Ye, Lihong. Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma. EBioMedicine. 2019, 45: 168-180. Doi: 10.1016/j.ebiom.2019.06.048.
Fang, Runping; Xu, Feifei; Shi, Hui;Wu, Yue; Cao, Can; Li, Hang; Ye, Kai; Zhang, Yingyi; Liu, Qian; Zhang, Shuqin; Zhang, Weiying; Ye, Lihong.LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity. Oncogene. 2020, 39(11): 2290-2304. Doi: 10.1038/s41388-019-1146-2.
Liu, Bowen; Wang, Tianjiao; Wang, Huawei; Zhang, Lu; Xu, Feifei; Fang, Runping; Li, Leilei; Cai, Xiaoli;Wu, Yue; Zhang, Weiying; Ye, Lihong. Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer. Journal of Hematology & Oncology. 2018, 11(1): 26. Doi: 10.1186/s13045-018-0577-5.
Group Members
Current Members:
Shaodong Yan, M.S. student（2020 class）
Yanchun Ma, M.S. student（2021 class）
Past Members:
N/A
E-mail：620034@sdnu.edu.cn
Telephone：
Office addr：Room 551, College of Life Sciences, Shandong Normal University
