Resume
2019-Present, College of Life Sciences, Shandong Normal University, Instructor
2012-2018, Northeast Normal University, Ph.D.
2008-2012, Jilin Normal University, B.S.
Research Areas
Meiosis is a specialized cell division process that generates haploid gametes form diploid germ cells. Defects in meiosis can cause errors in meiotic chromosome segregation, which are associated with infertility, miscarriages, birth defects, and tumorigenesis in humans. The structural morphology of chromosomes undergoes significant changes during meiosis, corresponding to a series of critical events include paring between homologous chromosomes, synaptonemal complex assembly linkage and homologous recombination. Our research group focuses on the Caenorhabditis elegans system and combines cell biology, genetics, proteomics and other methods to explore the structural basis and biological significance of meiotic chromosome dynamic changes.
Key words:Reproductive development; Meiosis; Synaptonemal complex; Homologous pairing; DNA damage repair
Honors and Awards
N/A
Selected Publications
Zhenguo Zhang; Songbo Xie;Ruoxi Wang; Shuqun Guo; Qiuchen Zhao; Hui Nie; Yuanyuan Liu; Fengguo Zhang; Miao Chen; Libo Liu; Xiaoqian Meng; Min Liu; Li Zhao; Monica P.Colaiácovo; Jun Zhou; Jinmin Gao. Multivalent weak interactions between assembly units drive synaptonemal complex formation. Journal of Cell Biology, 2020, 219(5): 1-19
Ruoxi Wang; Chunshuang Li; Ping Qiao; Yaoyao Xue; Xu Zheng; Hongyu Chen; Xianlu Zeng; Wenguang Liu; Istvan Boldogh; Xueqing Ba. OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos. Cell Death and Disease, 2018, 9(6): 1-15
Jiaxiang Li; Jinmin Gao;Ruoxi Wang. Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation. International Journal of Molecular Sciences, 2021, 22(12271): 1-15
Libo Liu; Jiaxiang Li; Yueshuang Ke; Xianlu Zeng; Jinmin Gao; Xueqing Ba;Ruoxi wang.The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogensis. Cellular and Molecular Life Sciences, 2022, 79(60): 1-15
Group Members
Current Members:
LiboLiu,M.S. student（2019class）
Mengfei Liu,M.S. student（2020class）
Xing Zhang, M.S. student（2021class）
PastMembers:
N/A
E-mail：wangruoxi@sdnu.edu.cn
Telephone：
Office addr：Room 532, College of Life Sciences, Shandong Normal University
