Resume
2022-Present, College of Life Sciences, Shandong Normal University, Associate Professor
2019-2021, College of Life Sciences, Shandong Normal University, Instructor
2013-2019, Peking University, Ph.D.
2009-2013, Soochow University, B.S.
Research Areas
We are interested in the fundamental research involving the cytoskeleton, autophagy, cell membrane and organelles, exploring the functions and mechanisms of the related organelles. We are especially interested in exploring the morphology and function of the microtubule-related structure, cilium. Our current study focuses on the molecular mechanisms of protein modifications and protein interactions underlying cilia assembling and disassembling, with a goal to understand how cilia play a role in physiological and pathological processes. We hope to explore the molecular mechanisms underlying ciliopathies and related diseases. We are also interested in the constitution and transduction of the related signal pathways, investigating how they are regulated. With cytological, biochemical and molecular methods, we hope to interpret the functions and mechanisms of the cilium-related signal pathways.
Key words:Cytoskeleton, cilium, cell membrane and organelle, signal transduction, ciliopathy
Honors and Awards
N/A
Selected Publications
1. Xiaoyu Tian*#, Huijie Zhao*, and Jun Zhou#. Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond. eLife, 2023, e87623. （#共同通讯作者）
2. Xiaoyu Tian*, Kaiyue Zhang*, Renjie Hong*, Hanyu Wang, Xifeng Dong, Jun Zhou, Yunfan Yang#, and Min Liu#. Primary cilia restrict autoinflammation by mediating PD-L1 expression, Science Bulletin, 2024.
3. Xiaoyu Tian, Ziyong Cui, Song Liu, Jun Zhou#, and Rutao Cui#. Melanosome transport and regulation in development and disease, Pharmacology & Therapeutics, 2021, 219: 107707.
4. Xiaoyu Tian, Junlin Teng#, and Jianguo Chen#. New insights regarding SNARE proteins in autophagosome-lysosome fusion, Autophagy, 2021, 17(10): 2680-2688.
5. Xiaoyu Tian, Pengli Zheng, Chenqian Zhou, Xurui Wang, Hua Ma, Wei Ma, Xiaokai Zhou, Junlin Teng#, and Jianguo Chen#. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B, Autophagy, 2020, 16(5): 797-810.
6. Renjie Hong*; Yanjie Tan*; Xiaoyu Tian*; Zhenzhou Huang; Jiaying Wang; Hua Ni; Jia Yang; Weiwen Bu; Song Yang; Te Li; Fan Yu; Weilong Zhong; Tao Sun; Xiaohong Wang; Dengwen Li; Min Liu; Yunfan Yang#; Jun Zhou#; XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis, EMBO reports, 2024, 25(3): 1055-1074. （*共同第一作者）
7. Pengli Zheng*, Qingzhou Chen*, Xiaoyu Tian*, Nannan Qian, Peiyuan Chai, Bing Liu, Junjie Hu, Craig Blackstone, Desheng Zhu, Junlin Teng#, and Jianguo Chen#. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling, Cell Research, 2018, 28(8): 833-854. （*共同第一作者）
8. Renjie Hong, Xiaoyu Tian, Hongbo Ma, Hua Ni, Jia Yang, Weiwen Bu, Te Li, Song Yang, Dengwen Li, Min Liu, and Yanjie Tan. Primary cilium-mediated signaling cascade suppresses age-related biliary fibrosis. 2023, Journal of Cellular Physiology, 2023, 238(11): 2600-2611.
9. Shuaiya Ma, Ye Tian, Jiali Peng, Chaojia Chen, Xueqi Peng, Fabao Zhao, Zhenyu Li, Mengzhen Li, Fangcheng Zhao, Xue Sheng, Runzhe Zong, Yiquan Li, Jiwei Zhang, Mingyan Yu, Qingfen Zhu, Xiaoyu Tian, Yuyang Li, Markus R Neckenig, Huiqing Liu, Peng Zhan, Xuetian Yue, Zhuanchang Wu, Lifen Gao, Xiaohong Liang, Xinyong Liu, Chunyang Li, and Chunhong Ma. Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Science Translational Medicine, 2023, 15(722), eadg6752.
Group Members
Current Members:
Song Liu, M.S. student（2019 class）
Kaiyue Zhang, M.S. student（2021 class）
Past Members:
N/A
E-mail：tianxiaoyu@sdnu.edu.cn
Telephone：
Office addr：Room 547, College of Life Sciences, Shandong Normal University
