动脉粥样硬化是冠心病、脑梗死、外周血管病等疾病的主要诱因。血管内皮细胞功能紊乱是动脉粥样硬化的重要标志，其表现为血管内皮细胞排列和细胞间隙异常，渗透压下降。纤毛对血管内皮细胞功能有重要调控作用，然而其动态变化及调控机理尚不清楚。本课题组研究方向为纤毛及相关信号通路在动脉粥样硬化发生发展中的作用。
Tan, Yanjie; Jin, Yi; Zhao, Pengxiang; Wu, Jian; Ren, Zhuqing. Lipid droplets contribute myogenic differentiation in C2C12 by promoting the remodeling of the acstin-filament. Cell Death & Disease, 2021, 12(12): 0-1102.
Tan Y, Jin Y, Wang Q, Huang J, Wu X, Ren Z. Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells. Cells. 2019 Oct 11;8(10):1241. doi: 10.3390/cells8101241.
Tan Y, Ma Z, Jin Y, Zong R, Wu J, Ren Z. MicroRNA 4651 regulates nonsense-mediated mRNA decay by targeting SMG9 mRNA. Gene. 2019 Jun 15;701:65-71. doi: 10.1016/j.gene.2019.03.031. Epub 2019 Mar 19.
Tan Y, Jin Y, Wu X, Ren Z. PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism. BMC Mol Biol. 2019 Nov 8;20(1):24. doi: 10.1186/s12867-019-0141-z
Tan Y, Jin Y, Wang S, Cao J, Ren Z. The RNA surveillance factor UPF1 regulates the migration and adhesion of porcine skeletal muscle satellite cells. J Muscle Res Cell Motil. 2021 Jun;42(2):203-217. doi: 10.1007/s10974-020-09585-4.PMID: 32990898
Jin Y,Tan Y, Chen L, Liu Y, Ren Z. Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression. Int J Mol Sci. 2018 Nov 2;19(11):3445. doi: 10.3390/ijms19113445.
Jin Y, Ren Z,Tan Y, Zhao P, Wu J. Motility Plays an Important Role in the Lifetime of Mammalian Lipid Droplets. Int J Mol Sci. 2021 Apr 7;22(8):3802. doi: 10.3390/ijms22083802.
Jin Y,Tan Y, Zhao P, Ren Z. SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis. Int J Mol Sci. 2020 Nov 2;21(21):8208. doi: 10.3390/ijms21218208.
Zhao P, Jin Y, Wu X, Huang J, Chen L,Tan Y, Yuan H, Wu J, Ren Z. Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity. Nanomaterials (Basel). 2022 Feb 17;12(4):672. doi: 10.3390/nano12040672.
He N, Ma D,Tan Y, Liu M. Upregulation of O-GlcNAc transferase is involved in the pathogenesis of acute myeloid leukemia. Asia Pac J Clin Oncol. 2021 Nov 24. doi: 10.1111/ajco.13685.
