Resume

2021-Present, College of Life Sciences, Shandong Normal University, Associate Professor

2016-2021, College of Life Sciences, Shandong Normal University, Instructor

20011-2016, Nankai University, Ph.D.

2007-2011, Shandong Normal University, B.S.

Research Areas

Cilia are hair-like organelles that protrude from the surface of many types of eukaryotic cells. Cilia are critical in many biological processes; motile cilia beat rhythmically and mainly function in cell locomotion and fluid transport, whereas non-motile primary cilia act as antennae for sensing extracellular signals. Consistent with the diverse roles of cilia, defects in their structure and/or function are associated with a variety of human diseases, collectively called ciliopathies. Also, ciliary assembly and length control are critical for maintenance of cilia homeostasis and the development of organ and tissues. However, the molecular mechanism of cilia homeostasis regulation and the role of cilia in various ciliopathies are still unknown. Dr. Jie Ran’s research interests focused on the regulation of ciliary homeostasis and the pathogenesis of various ciliopathies. Our long-term goal is to developing novel therapeutic strategies for ciliopathies. Currently, we are particularly interested in the following directions: 1. The molecular mechanisms of ciliary assembly and length control; 2. The function and molecular mechanisms of cilia in various development stages and ciliopathies; 3. The dysregulation of cilia in various ciliopathies and the therapeutic potential of targeting cilia in these ciliopathies.

Key words: cilium; microtubule; homeostasis; organ development; ciliopathy.

Honors and Awards

N/A

Selected Publications

1. Ran J,Li H, Zhang Y, et al. A non-mitotic role for Eg5 in regulating cilium formation and sonichedgehog signaling. Sci Bull. August 30 2021; 66 (16): 1620-1623. Doi: 10.1016/j.scib.2021.02.001

2. Ran J,Liu M, Feng J, et al. ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia. Dev Cell. May 4 2020;53(3):287-299 e5. doi:10.1016/j.devcel.2020.03.010

3. Ran J,Zhou J. Targeting the photoreceptor cilium for the treatment of retinal diseases. Acta Pharmacol Sin. Nov 2020;41(11):1410-1415. doi:10.1038/s41401-020-0486-3

4. Luo Y*,Ran J*, Xie S, et al. ASK1 controls spindle orientation and positioning by phosphorylating EB1 and stabilizing astral microtubules. Cell Discov. 2016;2:16033. doi:10.1038/celldisc.2016.33

5. Ran J,Yang Y, Li D, Liu M, Zhou J. Deacetylation of alpha-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly. Sci Rep. Aug 6 2015;5:12917. doi:10.1038/srep12917

6. Yang Y*,Ran J*, Sun L*, et al. CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism. Theranostics. 2015;5(7):656-66. doi:10.7150/thno.10844

7. Yang Y*,Ran J*, Liu M, et al. CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Res. Nov 2014;24(11):1342-53. doi:10.1038/cr.2014.136

Group Members

Current Members:

Yao Zhang, M.S. student（2019 class）

Sai Zhang, M.S. student（2020 class）

Guizhi Guo, M.S. student（2021 class）

Past Members:

Yuhan Wu, M.S. student（2016 class）

Jie Feng, M.S. student（2017 class）

Haixia Li, M.S. student（2018 class）

E-mail：jran@sdnu.edu.cn

Telephone：

Office addr：Room 550, College of Life Sciences, Shandong Normal University