Resume
2021-Present, College of Life Sciences, Shandong Normal University, Professor
2018-2020, The Ohio State University, Postdoctoral fellow
2017-2018, University of Nebraska Medical Center, Postdoctoral fellow
2014-2017, University of Colorado Boulder, Postdoctoral fellow.
2010-2014, Shandong University, Ph.D.
2007-2010, Shandong Academy of Medical Sciences, M.S.
2001-2005, Qufu Normal University, B.S.
Research Areas
Cell signaling is the key process to realize cell-cell communication, and it is also the basis for cells to sense and respond to external environmental stimuli. Signal transduction is closely related to diseases, so investigating the regulation of signal transduction is helpful to control the occurrence and development of diseases. Our laboratory is mainly engaged in studying the signal transduction regulatory mechanisms of innate immune responses to microbial infection. We will be focusing on investigating the functions of metabolic enzymes or metabolites in regulating innate immunity response using both macrophage and mice challenged with bacteria or viruses as infectious models. Our team will address the molecular mechanisms underlying the metabolic regulation of pathogenic microorganism infection. Our findings will provide the theoretical basis for designing and developing targeted drugs against pathogenic microorganism infection.
Key words:cell signaling, innate immunity, metabolism, virus, bacteria, inflammation.
Honors and Awards
2022, Shandong Science Fund for Excellent Young Scholars (Overseas)
2014, National Scholarship for Doctoral Students
2014, Outstanding Student and Student Cadre in Colleges and Universities of Shandong Province
2014, Outstanding Graduate of Shandong Province
2014, Outstanding Graduate of Shandong University
2013, President's Scholarship of Shandong University
2013, Outstanding Graduate Model of Shandong University
Selected Publications
Tianliang Li, Ligang Kong, Xinghui Li, Sijin Wu, Kuldeep S. Attri, Yan Li, Laura E. Herring, John M. Asara, Lei Xu, Yu L. Lei, Xiaolin Cheng, Pankaj K. Singh, Douglas R. Green, Haibo Wang and Haitao Wen. Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy. Nature Microbiology. 2021, 6(3):366-379.
Tianliang Li, Xinghui Li, Kuldeep S. Attri, Changhong Liu, Lupeng Li, Laura E. Herring, John M. Asara, Yu Lei, Pankaj K. Singh, Chengjiang Gao, and Haitao Wen. O-GlcNAc transferase links glucose metabolism to MAVS-mediated antiviral innate immunity. Cell Host Microbe. 2018, 24(6):791-803.
Tianliang Li, Ling Su, Ning Zhong, Xuexi Hao, Diansheng Zhong, Sunil Singhal and Xiangguo Liu. Salinomycin Induces Cell Death with Autophagy Through Activation of endoplasmic Reticulum Stress in Human Cancer Cells. Autophagy. 2013, 9(7):1057-1068.
Tianliang Li, Ling Su, Yuanjiu Lei, Xianfang Liu, Yajing Zhang, Xiangguo Liu. DDIT3 and KAT2A regulate TNFRSF10A and TNFRSF10B expression in endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells. J Biol Chem. 2015, 290(17):11108-18.
Xinghui Li, Wei Gong, Hao Wang,Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C.Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity. 2019, 50(3):576-590.
Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo,Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia, Y. Adam Yuan. Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction. Nature Communications. 2019, 10 (1): 3192.
Cong Zeng, Abdul A. Waheed,Tianliang Li, Jingyou Yu, Yi-Min Zheng, Jacob Yount, Haitao Wen, Eric O. Freed and Shan-Lu Liu. SERINC Proteins Potentiate Antiviral Type I IFN Induction and Proinflammatory Signaling Pathways. Science Signaling. 2021, 14(700):eabc7611.
Group Members
Current Members:
Renshuai Zhang, Ph.D. student（2019 class）
Lulu Sun, Ph.D. student（2021 class）
Tianyu Zhang, M.S. student（2021 class）
Wenqing Xu, M.S. student（2021 class）
Mengyu Zhang, M.S. student（2021 class）
Hengyu Wu, M.S. student（2021 class）
Past Members:
N/A
E-mail：tianliang.li@sdnu.edu.cn
Telephone：
Office addr：Room 534, College of Life Sciences, Shandong Normal University
