Yan ChenProfessorResume
2021-Present, College of Life Sciences, Shandong Normal University, Professor
2018-2021, Jinan University, Professor
2015-2018, Southwestern Medical Center, Postdoctoral fellow
2009-2014, Nankai University, Ph.D.
2005-2009, Nankai University, B.S.
Research Areas
Hypoxia is a hallmark of cancer that influences cancer cell function and is also an important component of the tumor microenvironment as it alters the cellular structure, angiogenesis, and metabolic reprogramming. Hypoxia-inducible factor (HIF) signaling, which is comprised of the key components (PHD, VHL, HIF) and a variety of other proteins, is a master player for sensing and adapting to hypoxia. High levels and activity of HIF result in poor clinical outcomes in cancer patients. Thus, HIFs provide ideal therapeutic targets for cancers. However, HIF biology is sophisticated, and currently available HIF inhibitors have limited clinical utility owing to their low efficacy or side effects. We will use integrated approaches, including proteomics, transcriptomic, mass spectrometry, xenografts and mouse models, to systematically investigate the effect and mechanism of HIF signaling in tumorigenesis and tumor progression. There are three main lines of research in Chen lab: (1) The mechanisms by which cancer cells sense and cope with hypoxia through PHD, VHL, or HIF; (2) The effect and mechanism of hypoxia-induced cellular structure changes in cancer metastasis; (3) Screen for small molecular inhibitors or develop novel PROTAC strategies to target HIF signaling.
Key words:Tumor hypoxia, HIF signaling, cell structure, inhibitor, PROTAC
Honors and Awards
2017, PDA travel award
Selected Publications
Huang, W., Liu, X., Zhang, Y., Deng, M., Li, G., Chen, G., Yu, L., Jin, L., Liu, T., Wang, Y., andChen, Y.(2022). USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2alpha. J Cell Physiol.
Wang, Y., Li, G., Deng, M., Liu, X., Huang, W., Zhang, Y., Liu, M., andChen, Y.(2021). The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics. Pharmacol Ther 221, 107783.
Wang, Y.,Chen, Y., Bao, L., Zhang, B., Wang, J. E., Kumar, A., Xing, C., Wang, Y., and Luo, W. (2020). CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors. Cancer Res 80, 3880-3891.
Chen, Y., Liu, M., Niu, Y., and Wang, Y. (2020). Romance of the three kingdoms in hypoxia: HIFs, epigenetic regulators, and chromatin reprogramming. Cancer Lett 495, 211-223.
Chen, Y., Zhang, B., Bao, L., Jin, L., Yang, M., Peng, Y., Kumar, A., Wang, J. E., Wang, C., Zou, X., et al. (2018). ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis. J Clin Invest 128, 1937-1955.
Group Members
Current Members:
Liang Zhang, Associate professor
Wei Xie, Associate professor
Fei Meng , Ph.D. student（2022 class）
Junru Qin, M.S. student（2021 class）
Min Wang, M.S. student（2021 class）
Shuo Wang, M.S. student（2021 class）
Tingting Yin, M.S.student（2021 class）
Junyan Zhou, M.S. student（2021 class）
Hongjie Li, M.S. student（2020 class）
Xiao Liu, M.S. student（2020 class）
Yu Wang , M.S.student（2020 class）
Mingzhen Chen, M.S. student（2019 class）
Jing Cai, M.S. student（2019 class）
E-mail：yanchen@sdnu.edu.cn
Telephone：
Office addr：Room 533, College of Life Sciences, Shandong Normal University
